What is CRPS?

Complex regional pain syndrome (CRPS) is a condition characterized by excessive, lingering pain in one of the limbs (arms, legs, hands, or feet), usually after an injury, trauma or surgery to that limb.

The pain is often accompanied by swelling, changes in skin color or temperature, abnormal sweating, joint stiffness, or abnormal muscular contractions, in the affected area. These changes may be mild or dramatic.

The pain has been described as burning or throbbing. There is often increased sensitivity in the affected area, such that even light touch or contact is painful. Unlike the normal pain which occurs after an injury, the pain of CRPS is often more severe than the initial injury and persists even after the initial injury or trauma has healed.

The exact cause of CRPS is unknown. However, abnormalities which have been observed in patients with CRPS and which may contribute to its cause include increased bone turnover in the affected limb, aberrant inflammation, abnormal constriction or dilation of blood vessels, and maladaptive changes in the brain.

CRPS was formerly referred to as reflex sympathetic dystrophy (RSD).

Download NIH CRPS Brochure

Who gets CRPS?


Anyone can get CRPS
It can strike at any age and affects both men and women, although it is much more common in women. The incidence of CRPS increases with age but the disease is also seen in children and teenagers.

CRPS seems to occur most often after fractures with surgery being the next most common precipitating event. Other injuries which can precipitate CRPS include sprains, contusions, and crush injuries.

A large patient survey revealed that patients likely to develop CRPS report a high level of pain in the week after wrist fracture.

Current Treatments


There is currently no drug approved for the treatment of CRPS.
Medicines used for more common pain conditions, such as opioids, NSAIDs, and neuropathic pain medications, are considered to be largely ineffective in CRPS, as demonstrated by controlled trials. Consequently, invasive and expensive palliative interventions, such as sympathetic blockades, surgical sympathectomy, and surgically implanted spinal cord stimulators, are often used although they carry a risk of significant complications.

Scientific Advisory Board


Asokumar Buvanendran,MD

William Gottschalk, Endowed Chair of Anesthesiology
Vice Chair Research & Director of Orthopedic Anesthesia
Professor, Department of Anesthesiology
Rush University Medical Center

Chris Gharibo,MD

Associate Professor of Anesthesiology & Orthopedics
Director of Chronic Pain Management
New York University, Hospital for Joint Diseases

Andreas Goebel,MSc (Pain Medicine),PhD,FFPMRCA,FRCA

Director Pain Research Institute
Senior Lecturer and Honorary Consultant in Pain Medicine
University of Liverpool
Walton Centre NHS Foundation Trust

Leonardo Kapural,MD,PhD

Professor of Anesthesiology
Wake Forest University
Clinical Director of the Chronic Pain Center
Wake Forest University Health Sciences Center

Nagy Mekhail,MD,PhD

Professor of Anesthesiology
Director of Evidence Based Pain Research
Cleveland Clinic