Knee OA Associated with Bone Marrow Lesions (BMLs)

Knee OA is a disorder characterized by bone changes around the knee joint, progressive loss of joint cartilage, joint space narrowing, and eventual total joint failure. Knee OA results in knee pain, significant physical disability, and reduced quality of life.

Some patients with knee OA exhibit BMLs. BMLs appear as areas of increased signal intensity on MRI of the knee, and are associated with and predict knee pain, disease severity, and structural progression in patients with knee OA, based on published studies. BMLs may therefore be a source of knee pain and a potential target for pharmaceutical intervention.