What is Treatment Resistant Depression?

Patients diagnosed with MDD (Major Depressive Disorder) are defined as having TRD if they have failed two or more antidepressant therapies.

MDD is a serious condition characterized by depressed mood or a loss of interest or pleasure in daily activities consistently for at least a two-week period, and which impairs social, occupational, educational, or other important functioning.

MDD is highly prevalent and difficult to treat. According to the National Institute of Health, or NIH, an estimated 6.7% of U.S. adults experience MDD each year, while 3.3% of individuals 13 to 18 years of age experience a seriously debilitating depressive disorder. Results of the Sequenced Treatment Alternatives to Relieve Depression, or STAR*D trial, funded by the National Institute of Mental Health, indicate that nearly two thirds of diagnosed and treated patients do not experience adequate treatment response with first line therapy, and that the majority of these initial failures also fail second line treatment.

Key Opinion Leader Presentations

Novel Approaches to Address Treatment Resistant Depression: Targeting Multiple Mechanisms of Action, Dr Maurizio Fava
April, 2018