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Chirality is a concept in chemistry that describes how two molecules that have the same number and types of atoms (isomers) can differ in their spatial arrangements (stereoisomers). Enantiomers are a pair of stereoisomers that are mirror images of each other and could not be superimposed in a three dimensional arrangement, similar to your right and left hands.

Our formulation chemistry has enabled us to isolate new and novel compounds such as our AXS-09 product candidate which contains the chirally pure S-enantiomer of bupropion. This novel formulation is supported through our success at isolating the S-enantiomer of bupropion into dosage forms that maintain their chirality. On the other hand, our AXS-05 product candidate contains racemic bupropion (equal amounts of the S– and R-enantiomers).

Axsome believes that the individual enantiomers of bupropion (R-bupropion and S-bupropion) may each have unique properties that render them potentially useful in different indications while continuing to inhibit dextromethorphan metabolism and thereby increase its blood concentration.